Article
Analysis of mutant frequencies and mutation spectra in hMTH1 knockdown TK6 cells exposed to UV radiation.
Mutation research - 1 Jan 2000
Fotouhi Asal, Hagos Winta Woldai, Ilic Marina, Wojcik Andrzej, Harms-Ringdahl Mats, de Gruijl Frank, Mullenders Leon, Jansen Jacob G, Haghdoost Siamak
Abstract excerpt
Ultraviolet radiation is a highly mutagenic agent that damages the DNA by the formation of mutagenic photoproducts at dipyrimidine sites and by oxidative DNA damages via reactive oxygen species (ROS). ROS can also give rise to mutations via oxidation of dNTPs in the nucleotide pool, e.g. 8-oxo-dGTP and 2-OH-dATP and subsequent incorporation during DNA replication. Here we show that expression of human MutT...
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