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Article

Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.

Biological chemistry - 1 Apr 2006

Nakabeppu Yusaku, Sakumi Kunihiko, Sakamoto Katsumi, Tsuchimoto Daisuke, Tsuzuki Teruhisa, Nakatsu Yoshimichi

Abstract excerpt

Genomes and their precursor nucleotides are highly exposed to reactive oxygen species, which are generated both as byproducts of oxygen respiration or molecular executors in the host defense, and by environmental exposure to ionizing radiation and chemicals. To counteract such oxidative damage in nucleic acids, mammalian cells are equipped with three distinct enzymes. MTH1 protein hydrolyzes oxidized purine...

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Identifiers

PMID: 16606334
DOI: 10.1515/BC.2006.050

Genes

MUTYH
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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