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Reduction of 8-oxodGTP in the nucleotide pool by hMTH1 leads to reduction in mutations in the human lymphoblastoid cell line TK6 exposed to UVA.

Mutation research - 1 Oct 2011

Fotouhi Asal, Skiöld Sara, Shakeri-Manesh Sara, Osterman-Golkar Siv, Wojcik Andrzej, Jenssen Dag, Harms-Ringdahl Mats, Haghdoost Siamak

Abstract excerpt

UVA has been suggested to play an important role in UV-induced mutagenesis. The mechanisms by which UVA induces mutations are still a matter of debate. Our aim was to investigate the protective capacity of hMTH1, a nucleotide pool sanitization enzyme with 8-oxodGTPase activity. Human B lymphoblastoid cells were stably transfected with shRNA directed against hMTH1. Clonogenic survival, mutations, intracellular and...

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Identifiers

PMID: 21784087
DOI: 10.1016/j.mrfmmm.2011.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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