Impact on outcomes of human leukocyte antigen matching by allele-level typing in adults with acute myeloid leukemia undergoing umbilical cord blood transplantation.

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Impact on outcomes of human leukocyte antigen matching by allele-level typing in adults with acute myeloid leukemia undergoing umbilical cord blood transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jan 2014

Sanz Jaime, Jaramillo Francisco J, Planelles Dolores, Montesinos Pau, Lorenzo Ignacio, Moscardó Federico, Martin Guillermo, López Francisca, Martínez Jesús, Jarque Isidro, de la Rubia Javier, Larrea Luis, Sanz Miguel A, Sanz Guillermo F

Abstract excerpt

This retrospective study analyzed the impact of directional donor-recipient human leukocyte antigen (HLA) disparity using allele-level typing at HLA-A, -B, -C, and -DRB1 in 79 adults with acute myeloid leukemia (AML) who received single-unit umbilical cord blood (UCB) transplant at a single institution. With extended high-resolution HLA typing, the donor-recipient compatibility ranged from 2/8 to 8/8. HLA...

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PMID: 24516896

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