Article
Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols.
Virology journal - 13 Jul 2020
Caputo Valeria, Diotti Roberta Antonia, Boeri Enzo, Hasson Hamid, Sampaolo Michela, Criscuolo Elena, Bagaglio Sabrina, Messina Emanuela, Uberti-Foppa Caterina, Castelli Matteo, Burioni Roberto, Mancini Nicasio, Clementi Massimo, Clementi Nicola
Abstract excerpt
BACKGROUND: Notwithstanding the efforts of direct-acting antivirals (DAAs) for the treatment of chronically infected hepatitis C virus (HCV) patients, concerns exist regarding the emergence of resistance-associated substitutions (RAS) related to therapy failure. Sanger sequencing is still the reference technique used for the detection of RAS and it detects viral variants present up to 15%, meaning that minority...
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