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Article

Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients.

International journal of molecular sciences - 27 Aug 2016

Marascio Nadia, Pavia Grazia, Strazzulla Alessio, Dierckx Tim, Cuypers Lize, Vrancken Bram, Barreca Giorgio Settimo, Mirante Teresa, Malanga Donatella, Oliveira Duarte Mendes, Vandamme Anne-Mieke, Torti Carlo, Liberto Maria Carla, Focà Alfredo

Abstract excerpt

Naturally occurring resistance-associated substitutions (RASs) can negatively impact the response to direct-acting antivirals (DAAs) agents-based therapies for hepatitis C virus (HCV) infection. Herein, we set out to characterize the RASs in the HCV1b genome from serum samples of DAA-naïve patients in the context of the SINERGIE (South Italian Network for Rational Guidelines and International Epidemiology, 2014)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27618896
DOI: 10.3390/ijms17091416
PMCID: PMC5037695

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