Article
Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing.
PloS one - 1 Jan 2014
Margeridon-Thermet Severine, Le Pogam Sophie, Li Lewyn, Liu Tommy F, Shulman Nancy, Shafer Robert W, Najera Isabel
Abstract excerpt
BACKGROUND AND OBJECTIVES: Hepatitis C virus (HCV) variants that confer resistance to direct-acting-antiviral agents (DAA) have been detected by standard sequencing technology in genotype (G) 1 viruses from DAA-naive patients. It has recently been shown that virological response rates are higher and breakthrough rates are lower in G1b infected patients than in G1a infected patients treated with certain classes of...
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