Article
Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitors.
Antimicrobial agents and chemotherapy - 1 May 2014
Di Maio V C, Cento V, Mirabelli C, Artese A, Costa G, Alcaro S, Perno C F, Ceccherini-Silberstein F
Abstract excerpt
Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed the NS5B polymerase genetic variability in circulating HCV genotypes/subtypes and its impact on the genetic barrier for the development of resistance to clinically relevant nucleoside inhibitors (NIs)/nonnucleoside inhibitors (NNIs). The study included 1,145 NS5B polymerase sequences retrieved from the Los Alamos HCV database and...
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