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Article

Validation of a Genotype-Independent Hepatitis C Virus Near-Whole Genome Sequencing Assay.

Viruses - 30 Aug 2021

Lapointe Hope R, Dong Weiyan, Dong Winnie W Y, Kirkby Don, Woods Conan, Poon Art F Y, Howe Anita Y M, Harrigan P Richard, Brumme Chanson J

Abstract excerpt

Despite the effectiveness of direct-acting antiviral agents in treating hepatitis C virus (HCV), cases of treatment failure have been associated with the emergence of resistance-associated substitutions. To better guide clinical decision-making, we developed and validated a near-whole-genome HCV genotype-independent next-generation sequencing strategy. HCV genotype 1-6 samples from direct-acting antiviral agent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34578305
DOI: 10.3390/v13091721
PMCID: PMC8473162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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