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Article

Evidence for a novel exon in the coding region of the adenomatous polyposis coli (APC) gene.

Genomics - 10 Aug 1995

Xia L, St Denis K A, Bapat B

Abstract excerpt

Germline mutations of the tumor suppressor gene APC cause familial adenomatous polyposis. Somatic APC alterations are involved in several sporadic neoplasms, including colorectal, duodenal, gastric, and esophageal carcinoma. The APC mRNA is encoded by 15 exons. Additional transcripts have been reported, due to alternative splicing of coding as well as noncoding regions. Two mRNA isoforms occur due to a deletion...

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Identifiers

PMID: 7490101
DOI: 10.1006/geno.1995.1195

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a novel exon in the coding region of the adenomatous polyposis coli (APC) gene.PMID 7490101Read ↗

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The adenomatous polyposis coli protein 30 years on.Semantic proximity Read ↗

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A novel indel in exon 9 of APC upregulates a 'skip exon 9' isoform and causes very severe familial adenomatous polyposis.Semantic proximity Read ↗

A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coliSemantic proximity Read ↗

Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15.Semantic proximity Read ↗

Detecting APC Gene Mutations in Familial Adenomatous Polyposis (FAP).Semantic proximity Read ↗

Novel and reported APC germline mutations in Chinese patients with familial adenomatous polyposis.Semantic proximity Read ↗

Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis.Semantic proximity Read ↗

Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype.Semantic proximity Read ↗

Nine novel APC mutations in Italian FAP patients.Semantic proximity Read ↗

Two novel mutations in exons 5 and 15 of the adenomatous polyposis coli (APC) gene.Semantic proximity Read ↗

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