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Article

Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory.

The Journal of biological chemistry - 28 May 2010

Papale Ligia A, Paul Ketema N, Sawyer Nikki T, Manns Joseph R, Tufik Sergio, Escayg Andrew

Abstract excerpt

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of transient depolarizing currents and play a critical role in the electrical signaling between neurons. A null mutation in the VGSC gene SCN8A, which encodes the transmembrane protein Na(v)1.6, was identified previously in a human family. Heterozygous mutation carriers displayed a range of phenotypes, including ataxia,...

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Identifiers

PMID: 20353942
DOI: 10.1074/jbc.M109.090084
PMCID: PMC2878034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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