Article
An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.
Experimental neurology - 1 Jan 2016
Makinson Christopher D, Dutt Karoni, Lin Frank, Papale Ligia A, Shankar Anupama, Barela Arthur J, Liu Robert, Goldin Alan L, Escayg Andrew
Abstract excerpt
Understanding the role of SCN8A in epilepsy and behavior is critical in light of recently identified human SCN8A epilepsy mutations. We have previously demonstrated that Scn8a(med) and Scn8a(med-jo) mice carrying mutations in the Scn8a gene display increased resistance to flurothyl and kainic acid-induced seizures; however, they also exhibit spontaneous absence seizures. To further investigate the relationship...
Topics
- Acoustic Stimulation
- Animals
- Brain Stem
- Disease Susceptibility
- Hippocampus
- Interneurons
- Male
- Mice
- Mice, Knockout
- Mutation
- NAV1.6 Voltage-Gated Sodium Channel