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Article

Early-life febrile seizures worsen adult phenotypes in Scn1a mutants.

Experimental neurology - 1 Jul 2017

Dutton Stacey B B, Dutt Karoni, Papale Ligia A, Helmers Sandra, Goldin Alan L, Escayg Andrew

Abstract excerpt

Mutations in the voltage-gated sodium channel (VGSC) gene SCN1A, encoding the Nav1.1 channel, are responsible for a number of epilepsy disorders including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS). Patients with SCN1A mutations often experience prolonged early-life febrile seizures (FSs), raising the possibility that these events may influence epileptogenesis and lead to more...

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Identifiers

PMID: 28373025
DOI: 10.1016/j.expneurol.2017.03.026
PMCID: PMC5538963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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