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Article

A new model to study sleep deprivation-induced seizure.

Sleep - 1 May 2015

Lucey Brendan P, Leahy Averi, Rosas Regine, Shaw Paul J

Abstract excerpt

BACKGROUND AND STUDY OBJECTIVES: A relationship between sleep and seizures is well-described in both humans and rodent animal models; however, the mechanism underlying this relationship is unknown. Using Drosophila melanogaster mutants with seizure phenotypes, we demonstrate that seizure activity can be modified by sleep deprivation. DESIGN: Seizure activity was evaluated in an adult bang-sensitive seizure...

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Identifiers

PMID: 25515102
DOI: 10.5665/sleep.4674
PMCID: PMC4402675

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