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Article

Failure to reabsorb the primary cilium induces cellular senescence

31 Dec 2018

Abstract excerpt

Aurora kinase A (AURKA) is necessary for proper primary cilium disassembly before mitosis. We found that depletion of caveolin-1 expression promotes primary cilia formation through the proteasomal-dependent degradation of aurora kinase A and induces premature senescence in human fibroblasts. Down-regulation of intraflagellar transport-88, a protein essential for ciliogenesis, inhibits premature senescence induced...

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PMID: 30596512
DOI: 10.1096/fj.201801382r

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