Article
RhoD participates in the regulation of cell-cycle progression and centrosome duplication.
Oncogene - 4 Apr 2013
Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton R G, Hoffmann I, Zerial M, Fotsis T, Murphy C
Abstract excerpt
We have previously identified a Rho protein, RhoD, which localizes to the plasma membrane and the early endocytic compartment. Here, we show that a GTPase-deficient mutant of RhoD, RhoDG26V, causes hyperplasia and perturbed differentiation of the epidermis, when targeted to the skin of transgenic mice. In vitro, gain-of-function and loss-of-function approaches revealed that RhoD is involved in the regulation of...
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