Article
F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation.
Cellular signalling - 1 Nov 2009
Hu Jinghui, Troglio Flavia, Mukhopadhyay Alka, Everingham Stephanie, Kwok Ester, Scita Giorgio, Craig Andrew W B
Abstract excerpt
Cdc42-Interacting Protein-4 (CIP4) family adaptors have been implicated in promoting Epidermal Growth Factor Receptor (EGFR) internalization, however, their unique or overlapping functions remain unclear. Here, we show that although CIP4 was not required for early events in clathrin-mediated endocytosis of EGFR, CIP4 localizes to vesicles containing EGFR and Rab5. Furthermore, expression of constitutively active...
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