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Article

Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005.

Nature communications - 23 Jun 2023

Pradhan Tejaswini, Sarkar Riddhiman, Meighen-Berger Kevin M, Feige Matthias J, Zacharias Martin, Reif Bernd

Abstract excerpt

Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid fibrils. Prior to fibril formation, soluble oligomeric AL protein has a direct cytotoxic effect on cardiomyocytes. We focus on the patient derived λ-III AL variable domain FOR005 which is mutated at five positions with respect to the closest germline protein. Using solution-state NMR spectroscopy, we follow the individual...

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Identifiers

PMID: 37353525
DOI: 10.1038/s41467-023-39280-0
PMCID: PMC10290123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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