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Article

Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.

Journal of molecular biology - 30 Sept 2005

Johnson Russell J K, Christodoulou John, Dumoulin Mireille, Caddy Gemma L, Alcocer Marcos J C, Murtagh Gareth J, Kumita Janet R, Larsson Göran, Robinson Carol V, Archer David B, Luisi Ben, Dobson Christopher M

Abstract excerpt

T70N human lysozyme is the only known naturally occurring destabilised lysozyme variant that has not been detected in amyloid deposits in human patients. Its study and a comparison of its properties with those of the amyloidogenic variants of lysozyme is therefore important for understanding the determinants of amyloid disease. We report here the X-ray crystal structure and the solution dynamics of T70N lysozyme,...

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Identifiers

PMID: 16126226
DOI: 10.1016/j.jmb.2005.07.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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