Why time matters: codon evolution and the temporal dynamics of dN/dS.

doi:10.1093/molbev/mst192

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Article

Why time matters: codon evolution and the temporal dynamics of dN/dS.

Molecular biology and evolution - 1 Jan 2014

Mugal Carina F, Wolf Jochen B W, Kaj Ingemar

Abstract excerpt

The ratio of divergence at nonsynonymous and synonymous sites, dN/dS, is a widely used measure in evolutionary genetic studies to investigate the extent to which selection modulates gene sequence evolution. Originally tailored to codon sequences of distantly related lineages, dN/dS represents the ratio of fixed nonsynonymous to synonymous differences. The impact of ancestral and lineage-specific polymorphisms on...

Topics

Amino Acid Substitution
Codon
Evolution, Molecular
Genetics, Population
Models, Genetic
Mutation
Phylogeny
Polymorphism, Genetic
Selection, Genetic
Time Factors

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Identifiers

PMID: 24129904
DOI: 10.1093/molbev/mst192
PMCID: PMC3879453

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