Statistical inference of selection and divergence from a time-dependent Poisson random field model.

doi:10.1371/journal.pone.0034413

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Article

Statistical inference of selection and divergence from a time-dependent Poisson random field model.

PloS one - 1 Jan 2012

Amei Amei, Sawyer Stanley

Abstract excerpt

We apply a recently developed time-dependent Poisson random field model to aligned DNA sequences from two related biological species to estimate selection coefficients and divergence time. We use Markov chain Monte Carlo methods to estimate species divergence time and selection coefficients for each locus. The model assumes that the selective effects of non-synonymous mutations are normally distributed across...

Topics

Animals
Drosophila melanogaster
Evolution, Molecular
Female
Genes, Insect
Male
Models, Genetic
Mutation
Phylogeny
Poisson Distribution
Polymorphism, Single Nucleotide
Selection, Genetic
Time Factors

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Open in PubMed Open full text

Identifiers

PMID: 22509300
DOI: 10.1371/journal.pone.0034413
PMCID: PMC3317977

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