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Article

The population genetics of dN/dS.

PLoS genetics - 1 Dec 2008

Kryazhimskiy Sergey, Plotkin Joshua B

Abstract excerpt

Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which represent substitutions that have fixed along independent lineages. Nevertheless, the dN/dS measure is often applied to sequences sampled from a single population, the...

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Identifiers

PMID: 19081788
DOI: 10.1371/journal.pgen.1000304
PMCID: PMC2596312

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