Article

Temporal Patterns of Deleterious Variations: Purifying Selection Across Evolutionary Timescales

2026-08-21

Abstract excerpt

The nearly neutral theory predicts that mildly deleterious mutations persist transiently within populations before being removed by purifying selection. During the past three decades, studies across diverse taxa, including humans, mammals, viruses, bacteria, and other vertebrates, have consistently reported a temporal pattern showing a higher proportion of deleterious variants at short timescales compared to that...

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Literature Corpus work: ec0825b6-c82f-5cb4-89d1-00ab5e3c8269
DOI: 10.20944/preprints202608.1482.v1

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