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Article

Comparisons of dN/dS are time dependent for closely related bacterial genomes.

Journal of theoretical biology - 21 Mar 2006

Rocha Eduardo P C, Smith John Maynard, Hurst Laurence D, Holden Matthew T G, Cooper Jessica E, Smith Noel H, Feil Edward J

Abstract excerpt

The ratio of non-synonymous (dN) to synonymous (dS) changes between taxa is frequently computed to assay the strength and direction of selection. Here we note that for comparisons between closely related strains and/or species a second parameter needs to be considered, namely the time since divergence of the two sequences under scrutiny. We demonstrate that a simple time lag model provides a general, parsimonious...

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Identifiers

PMID: 16239014
DOI: 10.1016/j.jtbi.2005.08.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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