Comparisons of dN/dS are time dependent for closely related bacterial genomes.

doi:10.1016/j.jtbi.2005.08.037

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Article

Comparisons of dN/dS are time dependent for closely related bacterial genomes.

Journal of theoretical biology - 21 Mar 2006

Rocha Eduardo P C, Smith John Maynard, Hurst Laurence D, Holden Matthew T G, Cooper Jessica E, Smith Noel H, Feil Edward J

Abstract excerpt

The ratio of non-synonymous (dN) to synonymous (dS) changes between taxa is frequently computed to assay the strength and direction of selection. Here we note that for comparisons between closely related strains and/or species a second parameter needs to be considered, namely the time since divergence of the two sequences under scrutiny. We demonstrate that a simple time lag model provides a general, parsimonious...

Topics

Bacteria
Evolution, Molecular
Genetic Variation
Genome, Bacterial
Models, Genetic
Mutation
Selection, Genetic
Stochastic Processes

Source

Open in PubMed

Identifiers

PMID: 16239014
DOI: 10.1016/j.jtbi.2005.08.037

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