Article
Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet.
American journal of physiology. Endocrinology and metabolism - 1 Dec 2013
Wada Tsutomu, Miyashita Yusuke, Sasaki Motohiro, Aruga Yusuke, Nakamura Yuto, Ishii Yoko, Sasahara Masakiyo, Kanasaki Keizo, Kitada Munehiro, Koya Daisuke, Shimano Hitoshi, Tsuneki Hiroshi, Sasaoka Toshiyasu
Abstract excerpt
Because the renin-angiotensin-aldosterone system has been implicated in the development of insulin resistance and promotion of fibrosis in some tissues, such as the vasculature, we examined the effect of eplerenone, a selective mineralocorticoid receptor (MR) antagonist, on nonalcoholic steatohepatitis (NASH) and metabolic phenotypes in a mouse model reflecting metabolic syndrome in humans. We adopted...
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