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Article

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis.

Hepatology (Baltimore, Md.) - 1 Jul 2014

Handa Priya, Maliken Bryan D, Nelson James E, Morgan-Stevenson Vicki, Messner Donald J, Dhillon Barjinderjit K, Klintworth Heather M, Beauchamp Mary, Yeh Matthew M, Elfers Clinton T, Roth Christian L, Kowdley Kris V

Abstract excerpt

UNLABELLED: Obesity and adiponectin depletion have been associated with the occurrence of nonalcoholic fatty liver disease (NAFLD). The goal of this study was to identify the relationship between weight gain, adiponectin signaling, and development of nonalcoholic steatohepatitis (NASH) in an obese, diabetic mouse model. Leptin-receptor deficient (Lepr(db/db) ) and C57BL/6 mice were administered a diet high in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24464605
DOI: 10.1002/hep.26946
PMCID: PMC5993561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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