Article
Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.
Molecular and cellular biochemistry - 1 Feb 2010
Malínská Hana, Oliyarnyk Olena, Hubová Miriam, Zídek Václav, Landa Vladimír, Simáková Miroslava, Mlejnek Petr, Kazdová Ludmila, Kurtz Theodore W, Pravenec Michal
Abstract excerpt
The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the...
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