Article
Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis.
The American journal of pathology - 1 Nov 2011
Itoh Michiko, Suganami Takayoshi, Nakagawa Nobutaka, Tanaka Miyako, Yamamoto Yukio, Kamei Yasutomi, Terai Shuji, Sakaida Isao, Ogawa Yoshihiro
Abstract excerpt
Obesity may be viewed as a state of chronic low-grade inflammation that participates in the development of the metabolic syndrome. Nonalcoholic steatohepatitis (NASH) is considered a hepatic phenotype of the metabolic syndrome and a high risk for progression to cirrhosis and hepatocellular carcinoma. Although the "two hit" hypothesis suggests involvement of excessive hepatic lipid accumulation and chronic...
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