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Article

Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet.

Journal of lipid research - 1 Nov 2017

Martin Gregory G, Landrock Danilo, Chung Sarah, Dangott Lawrence J, McIntosh Avery L, Mackie John T, Kier Ann B, Schroeder Friedhelm

Abstract excerpt

Upregulation of the hepatic endocannabinoid (EC) receptor [cannabinoid receptor-1 (CB1)] and arachidonoylethanolamide (AEA) is associated with nonalcoholic fatty liver disease (NAFLD). Male mice fed high-fat diet (HFD) ad libitum also exhibit NAFLD, increased hepatic AEA, and obesity. But, preference for HFD complicates interpretation and almost nothing is known about these effects in females. These issues were...

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Source

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Identifiers

PMID: 28972119
DOI: 10.1194/jlr.M077891
PMCID: PMC5665667

Genes

FABP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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