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Article

Medaka as a model for human nonalcoholic steatohepatitis.

Disease models & mechanisms - 1 Jan 2000

Matsumoto Toshihiko, Terai Shuji, Oishi Toshiyuki, Kuwashiro Shinya, Fujisawa Koichi, Yamamoto Naoki, Fujita Yusuke, Hamamoto Yoshihiko, Furutani-Seiki Makoto, Nishina Hiroshi, Sakaida Isao

Abstract excerpt

The global incidence of nonalcoholic steatohepatitis (NASH) is increasing and current mammalian models of NASH are imperfect. We have developed a NASH model in the ricefish medaka (Oryzias latipes), which is based on feeding the fish a high-fat diet (HFD). Medaka that are fed a HFD (HFD-medaka) exhibited hyperlipidemia and hyperglycemia, and histological examination of the liver revealed ballooning degeneration....

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Source

Identifiers

PMID: 20371730
DOI: 10.1242/dmm.002311

Genes

FAS
PPARA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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