Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.

Abstract excerpt

The critical and multiple roles of thrombin in blood coagulation are regulated by ligands and cofactors. Zymogen activation imparts proteolytic activity to thrombin and also affects the binding of ligands to its two principal exosites. We have used the activation peptide fragment 1.2 (F12), a ligand for anion-binding exosite 2, to probe the zymogenicity of thrombin by isothermal titration calorimetry. We show...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Thrombin
• Share to Allosteric Regulation
• Share to Blood Coagulation