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Article

Analysis of the evolution of the thrombin-inhibiting DNA aptamers using a genetic algorithm.

Biotechnology letters - 1 Dec 2006

Ikebukuro Kazunori, Yoshida Wataru, Noma Takahisa, Sode Koji

Abstract excerpt

We previously identified a thrombin-inhibiting DNA aptamer that was presumed to form a G-quartet structure with a duplex. To investigate the importance of the sequences in the duplex region and to obtain aptamers with higher inhibitory activities, we randomized the sequences of the duplex region of this aptamer and carried out selection based on inhibitory activity using a genetic algorithm. This method consisted...

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Identifiers

PMID: 17016675
DOI: 10.1007/s10529-006-9174-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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