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Article

Light Chain Mutation Effects on the Dynamics of Thrombin.

Journal of chemical information and modeling - 22 Feb 2021

Wu Dizhou, Xiao Jiajie, Salsbury Freddie R

Abstract excerpt

Thrombin plays an important role in the process of hemostasis and blood coagulation. Studies in thrombin can help us find ways to treat cancer because thrombin is able to reduce the characteristic hypercoagulability of cancer. Thrombin is composed of two chains, the light chain and the heavy chain. The function of the heavy chain has been largely explored, while the function of the light chain was obscured until...

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Identifiers

PMID: 33450154
DOI: 10.1021/acs.jcim.0c01303
PMCID: PMC8990444

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