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Article

A novel method of screening thrombin-inhibiting DNA aptamers using an evolution-mimicking algorithm.

Nucleic acids research - 7 Jul 2005

Ikebukuro Kazunori, Okumura Yuji, Sumikura Koichi, Karube Isao

Abstract excerpt

Thrombin-inhibiting DNA aptamers have already been obtained through the systematic evolution of ligands by exponential enrichment (SELEX). However, SELEX is a method that screens DNA aptamers that bind to their target molecules, and it sometimes fails to screen good inhibitors. Therefore, it is necessary to develop a method of screening DNA aptamers based on their inhibitory effects on the target molecules. We...

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Identifiers

PMID: 16002787
DOI: 10.1093/nar/gni108
PMCID: PMC1174901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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