Article
Multiplex detection of DNA mutations by the fluorescence fingerprint spectrum technique.
Angewandte Chemie (International ed. in English) - 2 Dec 2013
Song Jinzhao, Zhang Jiangyan, Lv Fengting, Cheng Yongqiang, Wang Bing, Feng Liheng, Liu Libing, Wang Shu
Abstract excerpt
A fingerprint spectrum technique that utilizes cationic conjugated-polymer-based fluorescence resonance energy transfer (FRET) is used for multiplex detection of DNA mutations. This method detects as low as 5 % mutation of the total DNA. Ten PIK3CA mutations originating from 30 clinical breast cancer samples could be detected.
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