Article
K-ras mutation detection by hybridization to a polypyrrole DNA chip.
Clinical chemistry - 1 Feb 2001
Lopez-Crapez E, Livache T, Marchand J, Grenier J
Abstract excerpt
BACKGROUND: Detection of mutations in cancer-related genes is of major importance for both basic knowledge and clinical practice. Several strategies have been developed to diagnose these alterations. We describe a method based on polypyrrole DNA chip technology to detect K-ras gene mutations in tumors. METHODS: An oligodeoxynucleotide array was constructed on a silicon device by copolymerization of...
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