Article
Profiling DNA mutation patterns by SERS fingerprinting for supervised cancer classification.
Biosensors & bioelectronics - 1 Oct 2020
Wu Lei, Teixeira Alexandra, Garrido-Maestu Alejandro, Muinelo-Romay Laura, Lima Luis, Santos Lúcio Lara, Prado Marta, Diéguez Lorena
Abstract excerpt
Profiling DNA mutation patterns for cancer classification plays an essential role in precision and personalized medicine. Conventional PCR-based mutation assay is limited by the extensive labour on target amplification. We herein create an amplification-free surface enhanced Raman spectroscopy (SERS) biochip which enables direct and simultaneous identification of multiple point mutations in tumor cells. Without...
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