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Article

Simple and Sensitive Method for Detecting Point Mutations of Epidermal Growth Factor Receptor Using Cationic Conjugated Polymers

25 Oct 2011

Abstract excerpt

The L858R mutation of epidermal growth factor receptor (EGFR) in nonsmall cell lung cancer is associated with the increased sensitivity to EGFR tyrosine kinase inhibitors. In this paper, a simple and sensitive method for identification of L858R mutation in cell lines and tumor tissues was developed using cationic conjugated polymer-based fluorescence resonance energy transfer technology (CCP-based FRET). The new...

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PMID: 22026576
DOI: 10.1021/am201248y

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