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Article

Improving acetate tolerance of Escherichia coli by rewiring its global regulator cAMP receptor protein (CRP).

PloS one - 1 Jan 2013

Chong Huiqing, Yeow Jianwei, Wang Ivy, Song Hao, Jiang Rongrong

Abstract excerpt

The presence of acetate exceeding 5 g/L is a major concern during E. coli fermentation due to its inhibitory effect on cell growth, thereby limiting high-density cell culture and recombinant protein production. Hence, engineered E. coli strains with enhanced acetate tolerance would be valuable for these bioprocesses. In this work, the acetate tolerance of E. coli was much improved by rewiring its global regulator...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24124618
DOI: 10.1371/journal.pone.0077422
PMCID: PMC3790751

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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