Article
Actuation of CRP activating region 3 by formylation modulates the Vibrio cholerae response to oxidative DNA damage.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2026
Santos Renato E R S, Basu Pallabi, O'Hara Brendan J, Gibson Jacob A, Gebhardt Michael J, Akut Chris, Robins William P, Mekalanos John J, Dove Simon L, Watnick Paula I
Abstract excerpt
The cyclic AMP receptor protein or CRP is a global regulator of bacterial metabolism. CRP activates transcription of genes required for utilization of alternative carbon sources in response to the second messenger cAMP, which is synthesized in the setting of glucose scarcity. Transcription is activated through contact with RNA polymerase at three sites termed activating regions (ARs) 1-3. AR3 was previously...
Read the complete abstract on PubMedTopics
- Cyclic AMP Receptor Protein
- Vibrio cholerae
- DNA Damage
- Gene Expression Regulation, Bacterial
- Oxidative Stress