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Article

Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse.

Genomics - 1 May 2006

Simon-Chazottes Dominique, Tutois Sylvie, Kuehn Michael, Evans Martin, Bourgade Franck, Cook Sue, Davisson Muriel T, Guénet Jean-Louis

Abstract excerpt

Positional cloning of two recessive mutations of the mouse that cause polysyndactyly (dan and mdig-Chr 2) confirmed that the gene encoding MEGF7/LRP4, a member of the low-density lipoprotein receptor family, plays an essential role in the process of digit differentiation. Pathologies observed in the mutant mice provide insight into understanding the function(s) of LRP4 as a negative regulator of the...

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Source

Identifiers

PMID: 16517118
DOI: 10.1016/j.ygeno.2006.01.007

Genes

LRP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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