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Article

Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors.

BMC medical genomics - 11 Oct 2013

Anaka Matthew, Hudson Christopher, Lo Pu-Han, Do Hongdo, Caballero Otavia L, Davis Ian D, Dobrovic Alexander, Cebon Jonathan, Behren Andreas

Abstract excerpt

BACKGROUND: Intratumoral heterogeneity is a major obstacle for the treatment of cancer, as the presence of even minor populations that are insensitive to therapy can lead to disease relapse. Increased clonal diversity has been correlated with a poor prognosis for cancer patients, and we therefore examined genetic, transcriptional, and functional diversity in metastatic melanoma. METHODS: Amplicon sequencing and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24119551
DOI: 10.1186/1755-8794-6-40
PMCID: PMC3852494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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