Article

Role of Intratumoral Heterogeneity in Metastatic Progression and Drug Resistance

2025-04-27

Abstract excerpt

Metastatic cancer is the final frontier in disease progression with few avenues of treatment open to patients. The failure of therapeutic options at the end-stage disease is confounded by the presence of diverse clones in the metastatic tumor which contributes to intratumoral heterogeneity (ITH) resulting in intrinsic and acquired drug resistance. We aim to elucidate the contribution of ITH to the development of m...

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Literature Corpus work: 3ce824ea-b929-5b95-b5a6-6fdeaa85d22f
DOI: 10.20944/preprints202504.1952.v1

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