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Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanoma

31 Oct 2019

Abstract excerpt

Originally described as interpatient variability, tumour heterogeneity has now been demonstrated to occur intrapatiently, within the same lesion, or in different lesions of the same patient. Tumour heterogeneity involves both genetic and epigenetic changes. Intrapatient heterogeneity is responsible for generating subpopulations of cancer cells which undergo clonal evolution with time. Tumour heterogeneity...

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PMID: 31672982
DOI: 10.1038/s41419-019-2048-5

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