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Article

Higher Mutation Burden in High Proliferation Compartments of Heterogeneous Melanoma Tumors.

International journal of molecular sciences - 9 Apr 2021

Grzywa Tomasz M, Koppolu Agnieszka A, Paskal Wiktor, Klicka Klaudia, Rydzanicz Małgorzata, Wejman Jarosław, Płoski Rafał, Włodarski Paweł K

Abstract excerpt

Melanoma tumors are the most heterogeneous of all tumor types. Tumor heterogeneity results in difficulties in diagnosis and is a frequent cause of failure in treatment. Novel techniques enable accurate examination of the tumor cells, considering their heterogeneity. The study aimed to determine the somatic variations among high and low proliferating compartments of melanoma tumors. In this study, 12 archival...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33918692
DOI: 10.3390/ijms22083886
PMCID: PMC8069012

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