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Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 May 2011

Ashton Thomas M, Mankouri Hocine W, Heidenblut Anna, McHugh Peter J, Hickson Ian D

Abstract excerpt

The Saccharomyces cerevisiae Rmi1 protein is a component of the highly conserved Sgs1-Top3-Rmi1 complex. Deletion of SGS1, TOP3, or RMI1 is synthetically lethal when combined with the loss of the Mus81-Mms4 or Slx1-Slx4 endonucleases, which have been implicated in Holliday junction (HJ) resolution. To investigate the causes of this synthetic lethality, we isolated a temperature-sensitive mutant of the RMI1...

Topics

DNA, Bacterial
DNA, Cruciform
DNA-Binding Proteins
Endonucleases
Escherichia coli Proteins
Flap Endonucleases
Holliday Junction Resolvases
Methyl Methanesulfonate
Mutation
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Temperature

Source

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Identifiers

PMID: 21343337
DOI: 10.1128/MCB.01130-10
PMCID: PMC3133222

Genes

RMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.PMID 21343337Read ↗

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