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Article

Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels.

Molecular cell - 10 Oct 2013

Sun Mai, Schwalb Björn, Pirkl Nicole, Maier Kerstin C, Schenk Arne, Failmezger Henrik, Tresch Achim, Cramer Patrick

Abstract excerpt

The rates of mRNA synthesis and degradation determine cellular mRNA levels and can be monitored by comparative dynamic transcriptome analysis (cDTA) that uses nonperturbing metabolic RNA labeling. Here we present cDTA data for 46 yeast strains lacking genes involved in mRNA degradation and metabolism. In these strains, changes in mRNA degradation rates are generally compensated by changes in mRNA synthesis rates,...

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PMID: 24119399
DOI: 10.1016/j.molcel.2013.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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