Article
scnRCA: a novel method to detect consistent patterns of translational selection in mutationally-biased genomes.
PloS one - 1 Jan 2013
O'Neill Patrick K, Or Mindy, Erill Ivan
Abstract excerpt
Codon usage bias (CUB) results from the complex interplay between translational selection and mutational biases. Current methods for CUB analysis apply heuristics to integrate both components, limiting the depth and scope of CUB analysis as a technique to probe into the evolution and optimization of protein-coding genes. Here we introduce a self-consistent CUB index (scnRCA) that incorporates implicit correction...
Topics
- Codon
- Databases, Genetic
- Genome
- Moraxellaceae
- Mutation
- Pseudomonas
- Selection, Genetic