Article
Optimal codon identities in bacteria: implications from the conflicting results of two different methods.
PloS one - 1 Jan 2011
Wang Bin, Shao Zhu-Qing, Xu Ying, Liu Jing, Liu Yuan, Hang Yue-Yu, Chen Jian-Qun
Abstract excerpt
A correlation method was recently adopted to identify selection-favored 'optimal' codons from 675 bacterial genomes. Surprisingly, the identities of these optimal codons were found to track the bacterial GC content, leading to a conclusion that selection would generally shape the codon usages to the same direction as the overall mutation does. Raising several concerns, here we report a thorough comparative study...
Topics
- Bacteria
- Base Composition
- Codon
- Gene Expression
- Genes, Bacterial
- Genome, Bacterial
- Mutation
- Protein Biosynthesis
- RNA, Transfer
- Selection, Genetic