A large-scale analysis of codon usage bias in 4868 bacterial genomes shows association of codon adaptation index with GC content, protein functional domains and bacterial phenotypes.

doi:10.1016/j.bbagrm.2022.194826

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Article

A large-scale analysis of codon usage bias in 4868 bacterial genomes shows association of codon adaptation index with GC content, protein functional domains and bacterial phenotypes.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Aug 2022

Masłowska-Górnicz Anna, van den Bosch Melanie R M, Saccenti Edoardo, Suarez-Diez Maria

Abstract excerpt

Multiple synonymous codons code for the same amino acid, resulting in the degeneracy of the genetic code and in the preferred used of some codons called codon bias usage (CBU). We performed a large-scale analysis of codon usage bias analysing the distribution of the codon adaptation index (CAI) and the codon relative adaptiveness index (RA) in 4868 bacterial genomes. We found that CAI values differ significantly...

Topics

Bacteria
Base Composition
Codon
Codon Usage
Genome, Bacterial
Phenotype

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Open in PubMed

Identifiers

PMID: 35605953
DOI: 10.1016/j.bbagrm.2022.194826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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